P4HA1

Across TCGA patient cohorts, P4HA1 mutation is significantly associated with the RNA expression of many other genes, with 2,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P4HA1-associated genes across cancer lineages are H3C11, PIGW, and PIGU. Each is linked with P4HA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HA1-to-partner and partner-to-P4HA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3C11 grouped by P4HA1-low versus P4HA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA1→partner) and Y-score (partner→P4HA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3C11 →	+0.505	+2.606	.002	<.001	3	2
UCEC	PIGW →	+0.505	+2.595	.007	<.001	3	2
SKCM	PIGU →	+0.425	+3.207	.006	.009	3	2
UCEC	UBE2I →	+0.327	+2.108	.003	.003	3	2
UCEC	EARS2 →	+0.541	+3.724	<.001	<.001	3	2
UCEC	KNOP1 →	+0.561	+2.828	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,029 associations by consensus.

H3C11 by P4HA1 expression — UCEC

Explore this box plot interactively →