P4HA1

Across TCGA cell cohorts, P4HA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,217 significant associations in total. BONE shows the largest number of these associations.

The most reproducible P4HA1-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, COPII-coated vesicle cargo loading, and Collagen fibril organization. Each is linked with P4HA1 in more than 16 cancer types. Because this analysis shows association rather than direction, both P4HA1-to-partner and partner-to-P4HA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by P4HA1-low versus P4HA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA1→partner) and Y-score (partner→P4HA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of protein exit from endoplasmic reticulum →	+0.142	+0.949	.009	.002	3	17
KIDNEY	COPII-coated vesicle cargo loading →	+0.134	+1.831	<.001	<.001	3	17
BONE	Collagen fibril organization →	+0.307	+1.220	<.001	<.001	3	15
BONE	Vesicle cargo loading →	+0.142	+1.951	<.001	<.001	3	14
LUNG_SCLC	Carbohydrate derivative catabolic process →	+0.094	+1.354	<.001	<.001	3	13
SOFT_TISSUE	Oligosaccharide catabolic process →	+0.199	+1.204	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,217 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by P4HA1 expression — OESOPHAGUS

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