P4HA1

Across TCGA cell cohorts, P4HA1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P4HA1-associated genes across cancer lineages are OPRPN, AVP, and AMELY. Each is linked with P4HA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P4HA1-to-partner and partner-to-P4HA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by P4HA1-low versus P4HA1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P4HA1→partner) and Y-score (partner→P4HA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	AMELY →	+0.261	+4.736	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TSGA10IP →	+0.086	+3.347	<.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.020	+3.347	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OPRPN by P4HA1 expression — URINARY_TRACT

Explore this box plot interactively →