P3H4

Across TCGA pan-cancer cohorts, P3H4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated P3H4 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher P3H4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated P3H4 expression acts as an unfavorable survival marker.

CCRCC, HNSC, and PDAC are the cancer types where P3H4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.524	0.865	<.001	110	view →
HNSC	DFS	Tertile	IV	0.541	0.878	.013	13	view →
PDAC	DFS	Quartile	III,IV	0.212	0.904	.006	13	view →
LSCC	DFS	Median	II,III,IV	0.697	0.846	.041	3	view →
GBM	DFS	Tertile	All	0.653	0.815	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

P3H4–CCRCC (DFS)

Open the CCRCC breakdown →