P3H2

Across TCGA pan-cancer cohorts, P3H2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated P3H2 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher P3H2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated P3H2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and LUSC are the cancer types where P3H2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.968	0.608	.005	34	view →
LUSC	DFS	Median	III,IV	0.010	0.754	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

P3H2–THYM (OS)

Open the THYM breakdown →