P3H2

Across TCGA patient cohorts, P3H2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,707 significant associations in total. GBM shows the largest number of these associations.

The most reproducible P3H2-associated genes across cancer lineages are IL1RAP, MTAPP2, and TREM1. Each is linked with P3H2 in more than 5 cancer types. Because this analysis shows association rather than direction, both P3H2-to-partner and partner-to-P3H2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P3H2 versus IL1RAP in UCEC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H2→partner) and Y-score (partner→P3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL1RAP →	+0.883	+0.481	.001	<.001	3	6
HNSC	MTAPP2 →	+1.775	+1.059	<.001	<.001	3	6
GBM	TREM1 →	+1.482	+0.551	<.001	<.001	3	5
GBM	RALGPS1 →	-0.744	-0.674	<.001	<.001	3	5
CCRCC	PLOD2 →	+0.972	+0.530	<.001	<.001	3	5
GBM	ANGPTL4 →	+1.303	+0.501	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,707 associations by consensus.

P3H2 vs IL1RAP — UCEC

Explore this scatter interactively →