P3H2

Across TCGA patient cohorts, P3H2 mutation is significantly associated with the RNA expression of many other genes, with 2,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H2-associated genes across cancer lineages are MIR4774, PLA2R1, and ZMYND19. Each is linked with P3H2 in more than 3 cancer types. Because this analysis shows association rather than direction, both P3H2-to-partner and partner-to-P3H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by P3H2-low versus P3H2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H2→partner) and Y-score (partner→P3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	4
UCEC	PLA2R1 →	-0.431	-2.071	.003	.005	3	3
UCEC	ZMYND19 →	+0.513	+2.091	<.001	<.001	3	3
SKCM	ENTR1 →	+0.408	+3.713	<.001	<.001	3	3
SKCM	RARRES2P2 →	+0.116	+1.382	.006	.005	3	3
BLCA	RNU6-794P →	+0.146	+4.007	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,271 associations by consensus.

MIR4774 by P3H2 expression — READ

Explore this box plot interactively →