P3H2

Across TCGA patient cohorts, P3H2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H2-associated genes across cancer lineages are Rb_pS807_S811, Caspase-8, and c-Kit. Each is linked with P3H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H2-to-partner and partner-to-P3H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb_pS807_S811 grouped by P3H2-low versus P3H2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H2→partner) and Y-score (partner→P3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rb_pS807_S811 →	+0.399	+3.459	.018	.005	3	2
UCEC	Caspase-8 →	-0.210	-2.558	.011	<.001	3	2
SKCM	c-Kit →	-0.523	-1.584	.041	.035	3	2
UCEC	Notch1 →	+0.155	+1.817	<.001	.015	3	2
UCEC	Akt_pT308 →	+0.420	+1.392	.043	.019	3	2
UCEC	STAT3_pY705 →	-0.370	-1.916	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Rb_pS807_S811 by P3H2 expression — SKCM

Explore this box plot interactively →