P3H2

Across TCGA cell cohorts, P3H2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible P3H2-associated genes across cancer lineages are CRISP1, CEACAM3, and KRTAP4-4. Each is linked with P3H2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H2-to-partner and partner-to-P3H2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP1 grouped by P3H2-low versus P3H2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H2→partner) and Y-score (partner→P3H2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CRISP1 →	+0.006	+5.321	.004	.005	3	1
CNS	CEACAM3 →	+0.075	+5.321	<.001	.005	3	1
CNS	KRTAP4-4 →	+0.022	+5.754	<.001	.002	3	1
CNS	MOS →	+0.044	+4.981	<.001	.008	3	1
BREAST	RBPJL →	+0.021	+3.784	.003	.006	3	1
BREAST	PATE1 →	+0.037	+3.080	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CRISP1 by P3H2 expression — CNS

Explore this box plot interactively →