P3H1

Across TCGA pan-cancer cohorts, P3H1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated P3H1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher P3H1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated P3H1 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where P3H1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	II,III,IV	0.228	0.979	.003	49	view →
PDAC	DFS	Median	III,IV	0.371	0.942	<.001	46	view →
LSCC	DFS	Median	II,III,IV	0.627	0.904	.004	12	view →
HNSC	DFS	Tertile	IV	0.548	0.833	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

P3H1–CCRCC (OS)

Open the CCRCC breakdown →