P3H1

Across TCGA patient cohorts, P3H1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,879 significant associations in total. GBM shows the largest number of these associations.

The most reproducible P3H1-associated genes across cancer lineages are CCN4, PCOLCE, and FN1. Each is linked with P3H1 in more than 9 cancer types. Because this analysis shows association rather than direction, both P3H1-to-partner and partner-to-P3H1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, P3H1 versus CCN4 in OV, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H1→partner) and Y-score (partner→P3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCN4 →	+1.474	+0.534	<.001	<.001	3	10
OV	PCOLCE →	+1.103	+0.627	<.001	<.001	3	10
OV	FN1 →	+2.073	+0.523	<.001	<.001	3	10
LSCC	PXDN →	+1.196	+0.512	<.001	<.001	3	10
BRCA	LOXL2 →	+1.310	+0.739	<.001	<.001	3	10
OV	ADAMTS12 →	+1.568	+0.549	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,879 associations by consensus.

P3H1 vs CCN4 — OV

Explore this scatter interactively →