P3H1

Across TCGA patient cohorts, P3H1 mutation is significantly associated with the RNA expression of many other genes, with 5,453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P3H1-associated genes across cancer lineages are MIR3126, LINC01022, and LINC01639. Each is linked with P3H1 in more than 3 cancer types. Because this analysis shows association rather than direction, both P3H1-to-partner and partner-to-P3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3126 grouped by P3H1-low versus P3H1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H1→partner) and Y-score (partner→P3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3126 →	+0.630	+5.010	<.001	.009	3	3
COAD	LINC01022 →	+0.328	+3.199	<.001	.005	3	3
LUSC	LINC01639 →	+0.756	+3.519	.001	.005	3	3
LUSC	RNA5SP288 →	+0.418	+3.588	.002	<.001	3	3
UCEC	NDUFAF5 →	+0.386	+3.133	<.001	<.001	3	3
BRCA	LINC02215 →	+0.132	+3.462	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,453 associations by consensus.

MIR3126 by P3H1 expression — CESC

Explore this box plot interactively →