P3H1

Across TCGA cell cohorts, P3H1 mutation is significantly associated with the RNA expression of many other genes, with 368 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P3H1-associated genes across cancer lineages are CBY1, DCTN6, and HFE. Each is linked with P3H1 in more than 1 cancer types. Because this analysis shows association rather than direction, both P3H1-to-partner and partner-to-P3H1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by P3H1-low versus P3H1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P3H1→partner) and Y-score (partner→P3H1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.902	+3.299	<.001	.004	3	1
LARGE_INTESTINE	DCTN6 →	+0.558	+3.212	.009	.006	3	1
LARGE_INTESTINE	HFE →	+0.865	+3.212	.004	.006	3	1
LARGE_INTESTINE	ACBD5 →	+0.974	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PHF12 →	+0.657	+3.212	.004	.006	3	1
LARGE_INTESTINE	MANBA →	+0.763	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

CBY1 by P3H1 expression — LARGE_INTESTINE

Explore this box plot interactively →