Across TCGA patient cohorts, P2RY4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY4-associated genes across cancer lineages are A-Raf_pS299, MEK1, and PCNA. Each is linked with P2RY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY4-to-partner and partner-to-P2RY4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY4→partner) and Y-score (partner→P2RY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.141	-2.584	.003	.010	3	2
UCEC	MEK1 →	+0.489	+3.807	<.001	<.001	3	2
UCEC	PCNA →	+0.225	+1.906	.009	.016	3	2
UCEC	EGFR_pY1068 →	-0.228	-1.906	.024	.016	3	1
UCEC	GATA6 →	-0.157	-1.693	.016	.044	3	1
UCEC	INPP4B →	-0.441	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

P2RY4 survival (RNA) · tumor vs normal (RNA) · all P2RY4 data types