P2RY2

Across TCGA patient cohorts, P2RY2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY2-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and Lck. Each is linked with P2RY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY2-to-partner and partner-to-P2RY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by P2RY2-low versus P2RY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY2→partner) and Y-score (partner→P2RY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.297	-2.502	.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.526	+3.479	.023	.002	3	2
COAD	Lck →	+0.429	+3.025	.006	.019	3	1
COAD	Dvl3 →	-0.238	-2.991	.027	.036	3	1
UCEC	14-3-3_beta →	-0.121	-2.886	.002	.001	3	1
UCEC	EGFR_pY1068 →	-0.253	-2.502	.010	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Rad50 by P2RY2 expression — UCEC

Explore this box plot interactively →