P2RY2

Across TCGA cell cohorts, P2RY2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RY2-associated genes across cancer lineages are GZMH, OR2AJ1, and C18orf63. Each is linked with P2RY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY2-to-partner and partner-to-P2RY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMH grouped by P2RY2-low versus P2RY2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY2→partner) and Y-score (partner→P2RY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GZMH →	+0.040	+6.357	<.001	<.001	3	1
BLOOD_Lymphoma	OR2AJ1 →	+0.042	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+4.029	<.001	.001	3	1
OVARY	DPPA5 →	+0.048	+5.196	<.001	.005	3	1
BLOOD_Leukemia	TLX3 →	+1.448	+3.944	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GZMH by P2RY2 expression — CNS

Explore this box plot interactively →