P2RY13

Across TCGA patient cohorts, P2RY13 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY13-associated genes across cancer lineages are Notch1, 14-3-3_beta, and Fibronectin. Each is linked with P2RY13 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY13-to-partner and partner-to-P2RY13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by P2RY13-low versus P2RY13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY13→partner) and Y-score (partner→P2RY13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.180	+1.700	.002	.044	3	2
UCEC	14-3-3_beta →	-0.101	-3.143	.017	.018	3	1
UCEC	Fibronectin →	-0.298	-2.575	.033	.010	3	1
UCEC	GATA6 →	-0.153	-2.985	.028	.034	3	1
UCEC	Heregulin →	-0.139	-2.986	.008	.035	3	1
UCEC	ACVRL1 →	-0.174	-2.680	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by P2RY13 expression — UCEC

Explore this box plot interactively →