P2RX6

Across TCGA patient cohorts, P2RX6 mutation is significantly associated with the RNA expression of many other genes, with 1,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX6-associated genes across cancer lineages are RNA5SP36, RPL23AP39, and RNY1P1. Each is linked with P2RX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RX6-to-partner and partner-to-P2RX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP36 grouped by P2RX6-low versus P2RX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX6→partner) and Y-score (partner→P2RX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP36 →	+0.136	+2.744	.009	.004	3	3
LIHC	RPL23AP39 →	+0.078	+4.758	<.001	.006	3	2
UCEC	RNY1P1 →	+0.215	+3.528	<.001	<.001	3	2
UCEC	TRDV3 →	+0.333	+2.024	<.001	.003	3	2
CESC	RNU6-20P →	+0.282	+3.381	.007	.003	3	2
BLCA	OR52K1 →	+0.078	+4.588	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,766 associations by consensus.

RNA5SP36 by P2RX6 expression — UCEC

Explore this box plot interactively →