P2RX6

Across TCGA patient cohorts, P2RX6 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX6-associated genes across cancer lineages are Shc_pY317, A-Raf_pS299, and Lck. Each is linked with P2RX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX6-to-partner and partner-to-P2RX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by P2RX6-low versus P2RX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX6→partner) and Y-score (partner→P2RX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.151	-2.459	.039	.020	3	2
UCEC	A-Raf_pS299 →	-0.166	-2.459	.004	.020	3	1
UCEC	Lck →	+0.370	+2.459	<.001	.020	3	1
UCEC	MEK1 →	+0.377	+3.000	.033	.036	3	1
UCEC	p62 Lck ligand →	+0.316	+3.179	.044	.010	3	1
UCEC	PDK1_pS241 →	+0.171	+2.472	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Shc_pY317 by P2RX6 expression — UCEC

Explore this box plot interactively →