P2RX6

Across TCGA cell cohorts, P2RX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,747 significant associations in total. BONE shows the largest number of these associations.

The most reproducible P2RX6-associated GO terms across cancer lineages are Protein targeting to lysosome involved in chaperone-mediated autophagy, Protein targeting to vacuole involved in autophagy, and Negative regulation of amyloid-beta formation. Each is linked with P2RX6 in more than 11 cancer types. Because this analysis shows association rather than direction, both P2RX6-to-partner and partner-to-P2RX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to lysosome involved in chaperone-mediated autophagy grouped by P2RX6-low versus P2RX6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX6→partner) and Y-score (partner→P2RX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.226	+1.587	<.001	<.001	3	12
BONE	Protein targeting to vacuole involved in autophagy →	+0.223	+1.413	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Negative regulation of amyloid-beta formation →	+0.138	+1.129	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Negative regulation of amyloid precursor protein catabolic process →	+0.130	+1.129	<.001	<.001	3	10
LIVER	Regulation of protein localization to mitochondrion →	+0.113	+1.113	.001	.002	3	10
BREAST	Regulation of intracellular protein transport →	+0.059	+0.667	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,747 associations by consensus.

Protein targeting to lysosome involved in chaperone-mediated autophagy by P2RX6 expression — BONE

Explore this box plot interactively →