P2RX5

Across TCGA patient cohorts, P2RX5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX5-associated genes across cancer lineages are 14-3-3_beta, Caspase-7-cleavedD198, and Caspase-8. Each is linked with P2RX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX5-to-partner and partner-to-P2RX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by P2RX5-low versus P2RX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX5→partner) and Y-score (partner→P2RX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-2.102	.006	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.733	+2.189	.004	.034	3	2
UCEC	Caspase-8 →	-0.241	-2.432	.028	.018	3	2
UCEC	EGFR_pY1068 →	-0.248	-2.115	.023	.019	3	1
UCEC	JNK2 →	+0.320	+2.115	<.001	.019	3	1
UCEC	MEK1 →	+0.492	+2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by P2RX5 expression — UCEC

Explore this box plot interactively →