P2RX3

Across TCGA patient cohorts, P2RX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX3-associated GO terms across cancer lineages are Axis specification, Endoplasmic reticulum organization, and Regulation of canonical Wnt signaling pathway. Each is linked with P2RX3 in more than 20 cancer types. Because this analysis shows association rather than direction, both P2RX3-to-partner and partner-to-P2RX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axis specification grouped by P2RX3-low versus P2RX3-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX3→partner) and Y-score (partner→P2RX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Axis specification →	+0.046	+0.121	<.001	<.001	3	21
ESCA	Endoplasmic reticulum organization →	+0.065	+0.460	<.001	<.001	3	18
TGCT	Regulation of canonical Wnt signaling pathway →	+0.048	+0.486	<.001	<.001	3	18
STAD	Regulation of embryonic development →	+0.050	+0.358	<.001	<.001	3	18
ESCA	Positive regulation of chromosome organization →	+0.053	+0.232	<.001	.005	3	17
TGCT	Positive regulation of Wnt signaling pathway →	+0.045	+0.477	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,091 associations by consensus.

Axis specification by P2RX3 expression — THYM

Explore this box plot interactively →