P2RX3

Across TCGA patient cohorts, P2RX3 mutation is significantly associated with the RNA expression of many other genes, with 1,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX3-associated genes across cancer lineages are RN7SL162P, POLR1G, and SLF1. Each is linked with P2RX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RX3-to-partner and partner-to-P2RX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL162P grouped by P2RX3-low versus P2RX3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX3→partner) and Y-score (partner→P2RX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SL162P →	+0.410	+5.428	<.001	<.001	3	3
SKCM	POLR1G →	+0.429	+3.227	.008	.009	3	2
SKCM	SLF1 →	+0.514	+3.719	.009	<.001	3	2
SKCM	APC →	+0.666	+2.591	.009	.006	3	2
UCEC	TAF9 →	+0.540	+3.480	<.001	.002	3	2
UCEC	RN7SL478P →	+0.181	+2.064	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,262 associations by consensus.

RN7SL162P by P2RX3 expression — COAD

Explore this box plot interactively →