P2RX3

Across TCGA cell cohorts, P2RX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 447 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible P2RX3-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Negative regulation of mRNA metabolic process, and Cellular response to nutrient levels. Each is linked with P2RX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both P2RX3-to-partner and partner-to-P2RX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by P2RX3-low versus P2RX3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX3→partner) and Y-score (partner→P2RX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of cilium assembly →	+0.056	+0.038	.003	.008	3	4
BLOOD_Lymphoma	Negative regulation of mRNA metabolic process →	+0.030	+0.020	.005	.005	3	4
BLOOD_Leukemia	Cellular response to nutrient levels →	+0.018	+0.025	.008	.009	3	4
BLOOD_Leukemia	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.038	+0.023	<.001	.006	3	4
OESOPHAGUS	Regulation of isotype switching to IgE isotypes →	-1.002	-0.030	.001	.007	3	4
OESOPHAGUS	Positive regulation of isotype switching to IgE isotypes →	-1.002	-0.030	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

Negative regulation of cilium assembly by P2RX3 expression — KIDNEY

Explore this box plot interactively →