P2RX3

Across TCGA cell cohorts, P2RX3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible P2RX3-associated genes across cancer lineages are OR10G2, KRTAP12-3, and FEV. Each is linked with P2RX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX3-to-partner and partner-to-P2RX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by P2RX3-low versus P2RX3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX3→partner) and Y-score (partner→P2RX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10G2 →	+0.014	+4.437	<.001	.004	3	2
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1
SKIN	FEV →	+0.140	+3.823	<.001	.006	3	1
SKIN	FAM187B →	+0.048	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR10G2 by P2RX3 expression — SKIN

Explore this box plot interactively →