P2RX1

Across TCGA pan-cancer cohorts, P2RX1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of P2RX1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where P2RX1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types P2RX1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where P2RX1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RX1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.647	<.001	7	view →
LUAD	Male	II,III,IV	−0.488	<.001	7	view →
LSCC	Male	II,III,IV	−0.383	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

P2RX1–COAD

Open the COAD breakdown →