OXTR

Across TCGA patient cohorts, OXTR mutation is significantly associated with the RNA expression of many other genes, with 2,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OXTR-associated genes across cancer lineages are FAM53B, MFSD14C, and LINC01128. Each is linked with OXTR in more than 1 cancer types. Because this analysis shows association rather than direction, both OXTR-to-partner and partner-to-OXTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM53B grouped by OXTR-low versus OXTR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OXTR→partner) and Y-score (partner→OXTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM53B →	+0.643	+2.818	<.001	.001	3	2
UCEC	MFSD14C →	+0.753	+2.839	<.001	.001	3	2
UCEC	LINC01128 →	+0.415	+3.354	<.001	.005	3	2
CESC	LINC02708 →	+0.103	+6.144	<.001	.001	3	2
UCEC	GLRX3 →	+0.557	+3.600	.002	.001	3	2
UCEC	HSD17B1 →	+0.380	+2.839	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,383 associations by consensus.

FAM53B by OXTR expression — UCEC

Explore this box plot interactively →