OXT

Across TCGA pan-cancer cohorts, OXT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated OXT data layer compared with 1 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher OXT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated OXT expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCS show a favorable association.

KIRP, OV, and SCLC are the cancer types where OXT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.960	0.829	<.001	80	view →
OV	DFS	Median	All	0.491	0.589	.001	56	view →
SCLC	OS	Median	III,IV	0.274	0.573	.007	47	view →
UCS	DFS	Quartile	III,IV	0.611	0.172	.001	44	view →
UVM	DFS	Quartile	All	0.799	0.460	.006	30	view →
UCEC	OS	Tertile	IV	0.686	0.292	.028	26	view →
LGG	DFS	Median	All	0.772	0.874	.005	16	view →
STAD	DFS	Tertile	IV	0.169	0.700	.027	12	view →
READ	OS	Tertile	II,III,IV	0.568	0.900	.014	12	view →
LUSC	OS	Quartile	All	0.276	0.517	.002	11	view →
LUAD	OS	Quartile	II,III,IV	0.838	0.642	.023	7	view →
ESCA	OS	Median	III,IV	0.302	0.523	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

OXT–KIRP (DFS)

Open the KIRP breakdown →