OXR1

Across TCGA patient cohorts, OXR1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OXR1-associated genes across cancer lineages are ATM, EGFR_pY1068, and eIF4E. Each is linked with OXR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OXR1-to-partner and partner-to-OXR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by OXR1-low versus OXR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OXR1→partner) and Y-score (partner→OXR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.535	-2.321	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.219	-1.637	.003	.001	3	2
COAD	eIF4E →	+0.227	+3.025	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.103	-2.415	.003	.002	3	2
UCEC	INPP4B →	-0.304	-2.584	.001	<.001	3	2
UCEC	MEK1 →	+0.336	+2.584	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by OXR1 expression — UCEC

Explore this box plot interactively →