OXCT1

Across TCGA pan-cancer cohorts, OXCT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of OXCT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OXCT1 RNA is repressed in tumor relative to normal tissue. In most cancer types OXCT1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BRCA are the cancer types where OXCT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OXCT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.254	<.001	11	view →
THCA	Male	III,IV	−1.204	<.001	10	view →
BRCA	All	All	−0.912	<.001	8	view →
LUSC	Female	All	+1.338	<.001	6	view →
LIHC	All	All	+0.722	<.001	6	view →
KIRP	Male	All	−0.877	.009	5	view →
CHOL	All	All	+1.787	.004	3	view →
READ	Female	All	−2.563	.001	2	view →
BLCA	Male	IV	−2.257	.020	2	view →
ESCA	All	II,III,IV	−1.824	.013	2	view →
STAD	Female	All	−0.971	.049	2	view →
LUAD	All	All	+0.344	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

OXCT1–KIRC

Open the KIRC breakdown →