OVOL3

Across TCGA cell cohorts, OVOL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,369 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OVOL3-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Negative regulation of calcium ion export across plasma membrane. Each is linked with OVOL3 in more than 9 cancer types. Because this analysis shows association rather than direction, both OVOL3-to-partner and partner-to-OVOL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by OVOL3-low versus OVOL3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OVOL3→partner) and Y-score (partner→OVOL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	mRNA alternative polyadenylation →	+0.042	+0.128	<.001	.003	3	9
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.117	+0.227	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.069	+0.102	.001	.002	3	9
PANCREAS	Telomere organization →	+0.042	+0.102	<.001	<.001	2	10
PANCREAS	DNA replication proofreading →	+0.144	+0.147	<.001	<.001	3	9
BONE	Establishment of spindle localization →	+0.076	+0.108	.002	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,369 associations by consensus.

mRNA alternative polyadenylation by OVOL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →