OVOL2

Across TCGA patient cohorts, OVOL2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OVOL2-associated genes across cancer lineages are EGFR_pY1068, Src_pY416, and Claudin-7. Each is linked with OVOL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OVOL2-to-partner and partner-to-OVOL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OVOL2-low versus OVOL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OVOL2→partner) and Y-score (partner→OVOL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.314	-3.169	.022	.020	3	1
UCEC	Src_pY416 →	-0.265	-3.156	.045	.020	3	1
UCEC	Claudin-7 →	-0.706	-3.169	.010	.020	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.796	+3.169	.004	.020	1	1
UCEC	mTOR_pS2448 →	-0.262	-3.169	.001	.020	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.708	-3.156	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by OVOL2 expression — UCEC

Explore this box plot interactively →