OVOL2

Across TCGA cell cohorts, OVOL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,158 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible OVOL2-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Response to indole-3-methanol, and Regulation of white fat cell proliferation. Each is linked with OVOL2 in more than 11 cancer types. Because this analysis shows association rather than direction, both OVOL2-to-partner and partner-to-OVOL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by OVOL2-low versus OVOL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OVOL2→partner) and Y-score (partner→OVOL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.217	+2.659	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Response to indole-3-methanol →	+0.235	+2.151	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of white fat cell proliferation →	-0.341	-2.305	<.001	<.001	3	12
LUNG_SCLC	Calcium-independent cell-cell adhesion →	+0.694	+3.583	.001	<.001	3	11
LUNG_NSCLC_LUSC	Serotonin secretion →	+2.239	+2.651	<.001	<.001	3	11
OVARY	Desmosome maintenance →	+1.538	+2.247	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,158 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by OVOL2 expression — LUNG_SCLC

Explore this box plot interactively →