OVGP1

Across TCGA patient cohorts, OVGP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OVGP1-associated genes across cancer lineages are Chk1, NF-kB-p65_pS536, and PDK1_pS241. Each is linked with OVGP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OVGP1-to-partner and partner-to-OVGP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by OVGP1-low versus OVGP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OVGP1→partner) and Y-score (partner→OVGP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.154	+1.749	.044	.049	3	2
SKCM	NF-kB-p65_pS536 →	-0.356	-1.906	.022	.016	3	1
SKCM	PDK1_pS241 →	-0.140	-2.397	.034	.003	3	1
SKCM	PEA-15_pS116 →	+0.296	+2.321	.012	.033	3	1
SKCM	CDK1_pY15 →	+0.271	+1.751	.036	.048	3	1
UCEC	EGFR_pY1068 →	-0.301	-4.247	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Chk1 by OVGP1 expression — SKCM

Explore this box plot interactively →