OVCA2

Across TCGA pan-cancer cohorts, OVCA2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated OVCA2 data layer compared with 1 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OVCA2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OVCA2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where OVCA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.781	0.340	.003	7	view →
HNSC	DFS	Median	III,IV	0.891	0.708	.023	5	view →
LSCC	DFS	Tertile	II,III,IV	0.489	0.839	.013	5	view →
LUAD	DFS	Median	III,IV	0.702	0.372	.027	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.730	0.464	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OVCA2–PDAC (DFS)

Open the PDAC breakdown →