OVCA2

Across TCGA patient cohorts, OVCA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 143 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OVCA2-associated GO terms across cancer lineages are Negative regulation of inflammasome-mediated signaling pathway, Peptidyl-lysine dimethylation, and Regulation of modification of postsynaptic actin cytoskeleton. Each is linked with OVCA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OVCA2-to-partner and partner-to-OVCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of inflammasome-mediated signaling pathway grouped by OVCA2-low versus OVCA2-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OVCA2→partner) and Y-score (partner→OVCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Negative regulation of inflammasome-mediated signaling pathway →	+0.139	+0.565	.001	.004	3	1
SCLC	Peptidyl-lysine dimethylation →	-0.141	-0.576	<.001	<.001	3	1
SCLC	Regulation of modification of postsynaptic actin cytoskeleton →	-0.167	-0.463	<.001	<.001	3	1
SCLC	Positive regulation of AMPA receptor activity →	-0.978	-0.501	<.001	<.001	3	1
SCLC	Regulation of neuron migration →	-0.092	-0.401	<.001	.003	3	1
SCLC	Pigment metabolic process →	+0.038	+0.630	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

Negative regulation of inflammasome-mediated signaling pathway by OVCA2 expression — SCLC

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