Across TCGA pan-cancer cohorts, OTX2P2 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OTX2P2’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OTX2P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTX2P2 is over-expressed in tumor.
LUSC are the cancer types where OTX2P2 tumor–normal differential expression is most reproducible.