OTX1

Across TCGA pan-cancer cohorts, OTX1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OTX1 data layer compared with 30 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher OTX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTX1 expression acts as an unfavorable survival marker.

KIRC, LIHC, and SARC are the cancer types where OTX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.062	0.789	<.001	32	view →
LIHC	DFS	Median	All	0.089	0.544	<.001	21	view →
SARC	OS	Median	All	0.133	0.860	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ESCA	DFS	Median	All	0.192	0.535	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OTX1–KIRC (OS)

Open the KIRC breakdown →