OTX1

Across TCGA patient cohorts, OTX1 protein abundance is significantly associated with the RNA expression of many other genes, with 306 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible OTX1-associated genes across cancer lineages are ELF4, NUBP1, and DNAJC2. Each is linked with OTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTX1-to-partner and partner-to-OTX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OTX1 versus ELF4 in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX1→partner) and Y-score (partner→OTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ELF4 →	-0.594	-1.183	.004	.002	3	1
BRCA	NUBP1 →	-0.679	-1.164	.002	.007	3	1
BRCA	DNAJC2 →	+0.701	+1.066	.004	.004	3	1
BRCA	LFNG →	-1.847	-1.685	.003	.002	3	1
BRCA	RALGPS2 →	-2.335	-1.632	.001	.006	3	1
BRCA	ECE1 →	-1.514	-1.196	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 306 associations by consensus.

OTX1 vs ELF4 — BRCA

Explore this scatter interactively →