OTX1

Across TCGA patient cohorts, OTX1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTX1-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with OTX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTX1-to-partner and partner-to-OTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by OTX1-low versus OTX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX1→partner) and Y-score (partner→OTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.180	+2.196	.011	.032	3	2
UCEC	MEK1 →	+0.466	+3.169	<.001	<.001	3	2
UCEC	MSH2 →	-0.174	-2.973	.036	.035	3	2
UCEC	TFRC →	+0.408	+3.459	.032	.005	2	3
UCEC	eIF4E →	+0.176	+2.000	.020	.030	3	1
UCEC	eIF4G →	+0.222	+2.321	.047	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

JNK2 by OTX1 expression — UCEC

Explore this box plot interactively →