OTX1

Across TCGA cell cohorts, OTX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,072 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTX1-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Positive regulation of DNA repair, and Regulation of DNA repair. Each is linked with OTX1 in more than 12 cancer types. Because this analysis shows association rather than direction, both OTX1-to-partner and partner-to-OTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by OTX1-low versus OTX1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX1→partner) and Y-score (partner→OTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.174	+0.876	.001	.008	3	13
BONE	Positive regulation of DNA repair →	+0.078	+0.784	.001	.004	3	12
BONE	Regulation of DNA repair →	+0.092	+1.035	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Copper ion export →	-0.176	-1.141	<.001	<.001	3	11
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.153	+0.967	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Viral transcription →	+0.115	+0.790	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,072 associations by consensus.

Transcription pausing by RNA polymerase II by OTX1 expression — BONE

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