OTX1

Across TCGA cell cohorts, OTX1 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTX1-associated genes across cancer lineages are AQP12B, FAM153CP, and GSG1L2. Each is linked with OTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTX1-to-partner and partner-to-OTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP12B grouped by OTX1-low versus OTX1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX1→partner) and Y-score (partner→OTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AQP12B →	+0.185	+2.940	<.001	.007	3	2
LARGE_INTESTINE	FAM153CP →	+0.244	+3.539	.003	.004	3	2
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	2
SOFT_TISSUE	DNTT →	+0.082	+3.006	.003	.006	3	1
SOFT_TISSUE	C20orf85 →	+0.061	+3.954	<.001	<.001	3	1
SOFT_TISSUE	SRMS →	+0.034	+3.491	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

AQP12B by OTX1 expression — SOFT_TISSUE

Explore this box plot interactively →