OTULINL

Across TCGA patient cohorts, OTULINL mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTULINL-associated genes across cancer lineages are Shc_pY317, EGFR_pY1068, and A-Raf_pS299. Each is linked with OTULINL in more than 1 cancer types. Because this analysis shows association rather than direction, both OTULINL-to-partner and partner-to-OTULINL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by OTULINL-low versus OTULINL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTULINL→partner) and Y-score (partner→OTULINL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.213	-2.700	<.001	.006	3	2
UCEC	EGFR_pY1068 →	-0.279	-1.906	.005	.016	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.459	.005	.005	3	1
UCEC	GATA6 →	-0.139	-2.444	.025	.018	3	1
UCEC	Heregulin →	-0.153	-2.415	.002	.003	3	1
UCEC	Myosin-IIa_pS1943 →	+0.180	+2.321	.030	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Shc_pY317 by OTULINL expression — UCEC

Explore this box plot interactively →