OTULIN

Across TCGA pan-cancer cohorts, OTULIN Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OTULIN data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher OTULIN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OTULIN expression acts as an unfavorable survival marker.

OV, READ, and BRCA are the cancer types where OTULIN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.028	0.844	<.001	48	view →
READ	OS	Median	All	0.166	0.830	<.001	20	view →
BRCA	DFS	Median	II,III,IV	0.170	0.889	<.001	8	view →
CESC	DFS	Median	All	0.091	0.543	.021	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	OS	Median	II,III,IV	0.563	0.677	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OTULIN–OV (OS)

Open the OV breakdown →