OTULIN

Across TCGA pan-cancer cohorts, OTULIN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OTULIN data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OTULIN mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OTULIN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, UCEC, and GBM are the cancer types where OTULIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.594	0.894	<.001	33	view →
UCEC	OS	Median	III,IV	1.000	0.494	.016	24	view →
GBM	DFS	Median	All	0.608	0.868	<.001	18	view →
LSCC	DFS	Quartile	II,III,IV	0.467	0.827	.013	11	view →
LUAD	OS	Tertile	All	0.614	0.924	.015	4	view →
CCRCC	OS	Median	All	0.906	0.984	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OTULIN–PDAC (OS)

Open the PDAC breakdown →