OTULIN

Across TCGA pan-cancer cohorts, OTULIN mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OTULIN’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where OTULIN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OTULIN is over-expressed in tumor.

CCRCC, HNSC, and LSCC are the cancer types where OTULIN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTULIN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.577	<.001	12	view →
HNSC	Male	All	+0.488	<.001	11	view →
LSCC	Female	II,III,IV	+0.572	<.001	8	view →
LUAD	Female	II,III,IV	+0.312	<.001	8	view →
PDAC	Female	All	+0.487	<.001	6	view →
COAD	All	All	+0.079	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

OTULIN–CCRCC

Open the CCRCC breakdown →