OTULIN

Across TCGA patient cohorts, OTULIN mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTULIN-associated genes across cancer lineages are ATM, c-Met_pY1235, and EGFR_pY1068. Each is linked with OTULIN in more than 1 cancer types. Because this analysis shows association rather than direction, both OTULIN-to-partner and partner-to-OTULIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by OTULIN-low versus OTULIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTULIN→partner) and Y-score (partner→OTULIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.576	-2.000	.004	.032	3	2
UCEC	c-Met_pY1235 →	+0.077	+2.700	.021	.006	3	2
UCEC	EGFR_pY1068 →	-0.245	-3.169	.030	.018	3	1
UCEC	EGFR_pY1173 →	+0.101	+2.026	.005	.018	2	2
UCEC	FASN →	+0.381	+2.000	.032	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-3.449	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by OTULIN expression — UCEC

Explore this box plot interactively →