OTULIN

Across TCGA cell cohorts, OTULIN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,555 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OTULIN-associated GO terms across cancer lineages are Phosphatidylinositol biosynthetic process, Positive regulation of cytoplasmic translation, and Protein localization to nuclear inner membrane. Each is linked with OTULIN in more than 15 cancer types. Because this analysis shows association rather than direction, both OTULIN-to-partner and partner-to-OTULIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol biosynthetic process grouped by OTULIN-low versus OTULIN-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTULIN→partner) and Y-score (partner→OTULIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Phosphatidylinositol biosynthetic process →	+0.053	+0.711	<.001	<.001	3	16
OESOPHAGUS	Positive regulation of cytoplasmic translation →	+0.132	+1.442	.005	.004	3	15
UPPER_AERODIGESTIVE_TRACT	Protein localization to nuclear inner membrane →	+0.167	+0.981	<.001	<.001	3	15
OESOPHAGUS	Signal transduction in response to DNA damage →	+0.057	+1.027	<.001	<.001	3	14
OESOPHAGUS	Nucleic acid transport →	+0.121	+1.288	.001	.001	3	14
OESOPHAGUS	RNA transport →	+0.121	+1.288	.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,555 associations by consensus.

Phosphatidylinositol biosynthetic process by OTULIN expression — CNS

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