OTUD7B

Across TCGA pan-cancer cohorts, OTUD7B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OTUD7B data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OTUD7B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OTUD7B expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where OTUD7B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.344	1.000	.009	23	view →
LSCC	DFS	Quartile	III,IV	0.400	1.000	.019	7	view →
LUAD	OS	Tertile	All	0.907	0.754	.040	4	view →
GBM	OS	Tertile	All	0.293	0.615	.042	3	view →
PDAC	OS	Median	II,III,IV	0.788	0.891	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OTUD7B–HNSC (OS)

Open the HNSC breakdown →