OTUD7B

Across TCGA patient cohorts, OTUD7B mutation is significantly associated with the RNA expression of many other genes, with 3,931 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD7B-associated genes across cancer lineages are IFI27L1, LSM3, and FAM210A. Each is linked with OTUD7B in more than 3 cancer types. Because this analysis shows association rather than direction, both OTUD7B-to-partner and partner-to-OTUD7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by OTUD7B-low versus OTUD7B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD7B→partner) and Y-score (partner→OTUD7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFI27L1 →	+0.385	+1.447	.001	.003	3	4
UCEC	LSM3 →	+0.494	+1.632	<.001	<.001	3	4
UCEC	FAM210A →	+0.304	+1.668	.005	.003	3	4
UCEC	SLC26A6 →	+0.398	+1.700	.001	.003	3	4
SKCM	RNA5SP248 →	+0.209	+2.437	<.001	.001	3	3
CESC	RNU6-1191P →	+0.510	+5.103	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,931 associations by consensus.

IFI27L1 by OTUD7B expression — UCEC

Explore this box plot interactively →